eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | li-fraumeni syndrome |
| Comorbidity | C0023448|lymphocytic leukemia |
| Sentences | 5 |
| PubMedID- 23732761 | [radiation-induced intracranial osteosarcoma after radiation for acute lymphocytic leukemia associated with li-fraumeni syndrome]. |
| PubMedID- 25766353 | Development of chronic myelogenous leukemia in a case of chronic lymphocytic leukemia with tp53 gene deletion. |
| PubMedID- 26489500 | [treatment of chronic lymphocytic leukemia with tp53 aberrations]. |
| PubMedID- 23525797 | In chronic lymphocytic leukemia (cll) patients, disruptions of the tp53 tumor suppressor pathway by 17p13 deletion (del17p), somatic tp53 mutations, or downregulation of microrna-34a have been associated with a poor prognosis. |
| PubMedID- 24997154 | Genomic complexity and ighv mutational status are key predictors of outcome of chronic lymphocytic leukemia patients with tp53 disruption. |
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